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"You miss a dose of Acyclovir, you should take the missed Acyclovir dosage as soon as possible after your symptoms begin. In oral, intravenous, and topical forms. If they become worse, check with your doctor. If your symptoms do not improve within a few days. Zovirax cream should never be used in eye, inside the mouth and nose as it is only for cutaneous use and it should be used by the patients for cold sores and reducing the length of the outbreak."