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Fluconazole has been associated with birth defects when given at high doses early in a pregnancy. Diflucan should not be taken in allergy to Fluconazole or other anti fungal azole preparations. Before taking Fluconazole, tell your doctor if you have a vaginal infection, do not have sex until you have finished your treatment. Fluconazole appears to be a safe and effective treatment for cutaneous leishmaniasis.