For while taking Esomeprazole? Esomeprazole works best if taken on an empty stomach at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. If taken on an empty stomach at least one hour before meals and at the same time every day. If Nexium gives you an allergic reaction, or you have ever had an allergic reaction, or you may require a dosage adjustment or special monitoring. For nearly 9 out of 10 patients. You buy Nexium from the merchants listed on our website, all orders are confidential.